Saccharin → HCID 14255069, compound

HRID 1761848Notes

Reaction equation

HRID 1761848 reaction equation
[CH3:1][CH:2]1[O:7][CH:6]([CH3:8])[CH2:5][N:4]([CH2:9][CH:10]([CH3:22])[CH2:11][CH:12]2[CH2:21][CH2:20][CH:19]3[CH:14]([CH2:15][CH2:16][CH2:17][CH2:18]3)[CH2:13]2)[CH2:3]1.[S:23]1([C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:27](=[O:28])[NH:26]1)(=[O:25])=[O:24]>CC(C)=O>[S:23]1([C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:27](=[O:28])[NH:26]1)(=[O:24])=[O:25].[CH3:8][CH:6]1[O:7][CH:2]([CH3:1])[CH2:3][N:4]([CH2:9][CH:10]([CH3:22])[CH2:11][CH:12]2[CH2:21][CH2:20][CH:19]3[CH:14]([CH2:15][CH2:16][CH2:17][CH2:18]3)[CH2:13]2)[CH2:5]1

Participants

4

Reactant 2

HCID 5143SaccharinHCID 14125799HCID 14125799, compound

Product 1

HCID 14255069HCID 14255069, compoundYield 101.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4.5 g (0.014 mol) of 1-(2,6-dimethylmorpholin-4-yl)-2-methyl-3-(decahydronaphth-2-yl)-propane and 2.58 g (0.014 mol) of saccharine are dissolved together in 80 ml of acetone and the solution is stirred at room temperature for 15 minutes. After the solvent has been evaporated off, 7 g (100% of theory) of 1-(2,6-dimethylmorpholin-4-yl)-2-methyl-3-(decahydronaphth-2-yl)-propane saccharine salt are obtained as an amorphous solid.

Workup

  1. customAfter the solvent has been evaporated off

Sources & evidence

ORD record
ord-913cf15adf87473ab7597e014dffa973
Source dataset
uspto-grants-1989_05
Patent number
US04829063

Reaction notes

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