反应详情

193 g of 5-chloro-3-formyl-2-hydroxybenzoic acid are dissoved in 2 liters of methanol and the solution is saturated with hydrogen chloride. 100 ml of thionyl chloride are added to the solution and the mixture is refluxed for 8 hours. After cooling, the resultant crystals are collected by filtration and dried to give 190 g of methyl 5-chloro-3-formyl-2-hydroxybenzoate.

1. temperaturethe mixture is refluxed for 8 hours
2. temperatureAfter cooling
3. filtrationthe resultant crystals are collected by filtration
4. customdried