反应详情

A mixture of 0.76 g of methyl 2-phenylbenzofuran-7-carboxylate, 0.46 g of 2-piperidinoethanol, 0.05 g of tetraisopropyl orthotitanate and 5 ml of xylene is refluxed for 4 hours. Toluene and an aqueous 10% sodium hydroxide solution are added to the reaction mixture and the mixture is filtered. The filtrate is washed with water, dried and evaporated to remove solvent. The residue is purified by silica gel column chromatography (solvent; chloroform:methanol=10:1) to give 1.01 g of 2-piperidinoethyl 2-phenylbenzofuran-7-carboxylate as pale yellow oil.

1. temperatureis refluxed for 4 hours
2. filtrationthe mixture is filtered
3. washThe filtrate is washed with water
4. customdried
5. customevaporated
6. customto remove solvent
7. customThe residue is purified by silica gel column chromatography (solvent; chloroform:methanol=10:1)