Tetrahydrofuran → HCID 19858304, compound

HRID 1762128Notes

Reaction equation

HRID 1762128 reaction equation
[NH:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6].O.C[N+]1([O-])CC[O:12]CC1.[O:16]1C[CH2:19][CH2:18][CH2:17]1>[Os](=O)(=O)(=O)=O>[OH:12][CH:18]([CH2:17][OH:16])[CH2:19][N:1]1[CH2:5][CH2:4][NH:3][C:2]1=[O:6]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 84532-Imidazolidinone2×HCID 2724197N-Methylmorpholine N-oxide monohydrate

Product 1

HCID 19858304HCID 19858304, compound

Reagents, catalysts & solvents 1

HCID 30318Osmium TetroxideCatalyst

Procedure

In the fourth step, a 0.4M solution of osmium tetroxide (0.05 mole for each mole of XI) is added dropwise to a solution in tetrahydrofuran of the intermediate (XI) and 4-methylmorpholine-4-oxide monohydrate (two moles for each mole of intermediate) and the resulting mixture stirred for 16 to 20 hours to obtain the 3-(2,3-dihydroxypropyl)imidazolidinone intermediate (XII) in the reaction mixture which may then be recovered employing conventional procedures.

Sources & evidence

ORD record
ord-8753efda4bc047b9a1c9d95614609794
Source dataset
uspto-grants-1989_05
Patent number
US04831035

Reaction notes

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