反应详情

Methyl 4-(2-Bromoethoxy)benzoate (126.52 g) and 99.5 g of potassium salt of phthalimide were dissolved in 600 ml of N,N-dimethylformamide and the solution was stirred at 78°-80° C. for 2 hours. The reaction solution was poured over ice water and extracted with chloroform. The chloroform layer was washed with water twice, dried with anhydrous magnesium sulphate, and concentrated in vacuo whereupon the residue was crystallised. Ether was added to the residue and filtered to give crystals in 149.23 g (yield: 94%). M.p. 129°-130.5° C.

1. extractionextracted with chloroform
2. washThe chloroform layer was washed with water twice
3. dry with materialdried with anhydrous magnesium sulphate
4. concentrationconcentrated in vacuo whereupon the residue
5. customwas crystallised
6. additionEther was added to the residue
7. filtrationfiltered
8. customto give crystals in 149.23 g (yield: 94%)