Hydrochloric Acid → HCID 20042545, compound

HRID 1762219Notes

Reaction equation

HRID 1762219 reaction equation
[OH:1][CH2:2][C:3]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][OH:25])[C:4]=1[CH2:5][O:6][C:7]1[C:8]2[N:9]([C:13]([CH2:17][C:18]#[CH:19])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1.[ClH:26]>CO>[ClH:26].[OH:25][CH2:24][C:20]1[CH:21]=[CH:22][CH:23]=[C:3]([CH2:2][OH:1])[C:4]=1[CH2:5][O:6][C:7]1[C:8]2[N:9]([C:13]([CH2:17][C:18]#[CH:19])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14368371HCID 14368371, compound

Product 1

HCID 20042545HCID 20042545, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 8-[2,6-bis(hydroxymethyl)benzyloxy]-2-methyl-3-(2-propynyl)imidazo[1,2-a]pyridine (4.9 g) in methanol (80 ml) was added 1 N hydrochloric acid (15 ml) at room temperature. The obtained clear solution was concentrated under reduced pressure and the residue was recrystallized from a mixture of acetone (100 ml) and water (8 ml) to give 8-[2,6-bis(hydroxymethyl)benzyloxy]-2-methyl-3-(2-propynyl)imidazo[1,2-a]pyridine hydrochloride (4.44g)

Workup

  1. concentrationThe obtained clear solution was concentrated under reduced pressure
  2. customthe residue was recrystallized from a mixture of acetone (100 ml) and water (8 ml)

Sources & evidence

ORD record
ord-fffe213b2c31483d8ab90bc9aa2ca561
Source dataset
uspto-grants-1989_05
Patent number
US04831041

Reaction notes

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