Potassium Carbonate → HCID 19819650, compound

HRID 1762554Notes

Reaction equation

HRID 1762554 reaction equation
[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[NH:11][C:10](=[O:15])[N:9]([CH3:16])[C:8]=2[N:7]=[CH:6]1)[CH2:2][CH:3]=[CH2:4].Cl[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:25])([CH3:24])[CH3:23].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:18][CH2:19][CH2:20][CH2:21][C:22]([OH:25])([CH3:24])[CH3:23])[C:10](=[O:15])[N:9]([CH3:16])[C:8]=2[N:7]=[CH:6]1)[CH2:2][CH:3]=[CH2:4]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 13298149HCID 13298149, compoundHCID 137476791-Chloro-5-hydroxy-5-methylhexane

Product 1

HCID 19819650HCID 19819650, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

22 g (0.1 mol) of the xanthine from stage (a) are reacted with 16.6 g (0.11 mol) of 1-chloro-5-hydroxy-5-methylhexane (Example 1a) and 15.2 g (0.11 mol) of potassium carbonate in 500 ml of dimethylformamide under the experimental conditions described in Example 2, and the mixture is worked up. The reaction product is obtained in pure form without prior column chromatography, by recrystallization once from ethyl acetate with the addition of petroleum ether, at the boil.

Workup

  1. customThe reaction product is obtained in pure form without prior column chromatography
  2. customby recrystallization once from ethyl acetate
  3. additionwith the addition of petroleum ether

Sources & evidence

ORD record
ord-65c79fea86984e299f1b15b3195fecea
Source dataset
uspto-grants-1989_05
Patent number
US04833146

Reaction notes

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