反应详情

A mixture of 2 g of 4-fluoro-3-phenoxy-benzaldehyde, 5 ml of dimethylforomamide, 2 g of electrolytic zinc and 15 ml of a solution of 13.5 mmols of trifluoromethyl iodide in dimethylformamide was ultrasonically irradiated for 15 minutes and the mixture was poured into aqueous N hydrochloric acid. The mixture was extracted with isopropyl ether and the organic phase was evaporated to dryness under reduced pressure. The residue was chromatographed over silica gel and was eluted with a 1-1 methylene chloride-hexane mixture to be obtain 1.5 g of 1-(4-fluoro-3-phenoxy-phenyl)-2,2,2-trifluoroethanol.

1. customwas ultrasonically irradiated for 15 minutes
2. extractionThe mixture was extracted with isopropyl ether
3. customthe organic phase was evaporated to dryness under reduced pressure
4. customThe residue was chromatographed over silica gel
5. washwas eluted with a 1-1 methylene chloride-hexane mixture