Phosphorus oxychloride → HCID 20039456, compound

HRID 1762777Notes

Reaction equation

HRID 1762777 reaction equation
O=P(Cl)(Cl)Cl.[CH2:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26](=O)[NH2:27])=[CH:22][CH:21]=2)=[O:17])=[CH:11][CH:10]=1)[CH3:7]>CN(C=O)C>[CH2:6]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][C:16]([O:18][CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]#[N:27])=[CH:24][CH:25]=2)=[O:17])=[CH:13][CH:14]=1)[CH3:7]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 20039404HCID 20039404, compound

Product 1

HCID 20039456HCID 20039456, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

65 g of POCl3 is added dropwise at 50° and while stirring to a solution, in 500 ml of DMF, of 31.3 g of p-carbamoylbenzyl p-ethoxyphenylacetate (obtainable by esterification). After stirring for a further hour, the mixture is poured onto ice and worked up in a customary manner to give p-cyanobenzyl p-ethoxyphenylacetate, m.p. 59°, c.p. -40°.

Workup

  1. additionthe mixture is poured onto ice

Sources & evidence

ORD record
ord-8cfa3503faa54dfd999f7acd6589a406
Source dataset
uspto-grants-1989_05
Patent number
US04834905

Reaction notes

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