反应详情

温度

25 °C

To a solution of 1-(3,5-difluorobenzyl)-2-mercaptoimidazole-5-carboxylic acid (2.70 g, 0.01 moles) in tetrahydrofuran (25 ml) was added N-hydroxysuccinimide (1.27 g, 0.011 mole) followed by dropwise addition of dicyclohexylcarbodiimide (2.06 g, 0.01 mole) in tetrahydrofuran (30 ml). A solution of N-methylpiperazine (1.22 ml, 0.011 mole) in tetrahydrofuran (10 ml) was added and the mixture stirred at 25° C. for 2 hours and then at 40° C. for 16 hours. Additional N-methylpiperazine (1.0 ml, 0.009 mole) was added and the reaction mixture was stirred at 40° C. for 1.5 hours. The reaction mixture was filtered and the solvent removed under vacuum. The residue was dissolved in ethyl acetate and was washed with dilute sodium carbonate, water, and brine. The solution was dried and the solvent removed under vacuum. The resulting solid was triturated with ether and the product was filtered and dried to give a solid, m.p.: 243°-244° C. (2.10 g, 60%).

1. waitat 40° C. for 16 hours
2. stirringthe reaction mixture was stirred at 40° C. for 1.5 hours
3. filtrationThe reaction mixture was filtered
4. customthe solvent removed under vacuum
5. dissolutionThe residue was dissolved in ethyl acetate
6. washwas washed with dilute sodium carbonate, water, and brine
7. customThe solution was dried
8. customthe solvent removed under vacuum
9. customThe resulting solid was triturated with ether
10. filtrationthe product was filtered
11. customdried
12. customto give a solid, m.p.: 243°-244° C. (2.10 g, 60%)