HCID 70381752, compound → HCID 70381301, compound

HRID 1762943Notes

Reaction equation

HRID 1762943 reaction equation
[ClH:1].[C:2]1([O:8][C:9]([C:11]2[NH:12][C:13]3[C:18]([CH:19]=2)=[C:17]([C:20](=[O:27])[CH2:21][NH:22][C:23]([CH3:26])([CH3:25])[CH3:24])[CH:16]=[CH:15][C:14]=3[OH:28])=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.O1CCCC1>[ClH:1].[C:2]1([O:8][C:9]([C:11]2[NH:12][C:13]3[C:18]([CH:19]=2)=[C:17]([CH:20]([OH:27])[CH2:21][NH:22][C:23]([CH3:24])([CH3:26])[CH3:25])[CH:16]=[CH:15][C:14]=3[OH:28])=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 70381752HCID 70381752, compound

Product 1

HCID 70381301HCID 70381301, compoundYield 89.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Under the conditions of Example 14(E), 1.5 g of 4-tert-butylaminoacetyl-7-hydroxyindole-2-carboxylic acid phenyl ester hydrochloride is hydrogenated in a mixture of 40 ml of methanol and 40 ml of tetrahydrofuran and worked up, thus producing 1.35 g of 4-(2-tert-butylamino-1-hydroxy-ethyl)-7-hydroxyindole-2-carboxylic acid phenyl ester hydrochloride, decomposition point 165°-166° C.

Sources & evidence

ORD record
ord-267fc70491a148059ef435b4126e56ce
Source dataset
uspto-grants-1989_05
Patent number
US04835175

Reaction notes

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