HCID 13242194, compound → 2-(Dimethylamino)ethyl 7-hydroxy-1H-indole-2-carboxylate

HRID 1762944Notes

Reaction equation

HRID 1762944 reaction equation
[CH3:1][N:2]([CH3:25])[CH2:3][CH2:4][O:5][C:6]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[CH:12][C:11]=2[O:17]CC1C=CC=CC=1)=[O:7]>CO.O1CCCC1>[CH3:1][N:2]([CH3:25])[CH2:3][CH2:4][O:5][C:6]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[CH:12][C:11]=2[OH:17])=[O:7]

Participants

4

Reactant 1

HCID 13242194HCID 13242194, compound

Product 1

HCID 132421952-(Dimethylamino)ethyl 7-hydroxy-1H-indole-2-carboxylateYield 56%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Under the conditions of Example 14(C), 9 g of 7-benzyloxyindole-2-carboxylic acid 2-dimethylaminoethyl ester is hydrogenated in a mixture of 50 ml of methanol and 50 ml of tetrahydrofuran and worked up, yielding 3.7 g of 7-hydroxyindole-2-carboxylic acid 2-dimethylaminoethyl ester, mp 149°-152° C.

Sources & evidence

ORD record
ord-298b8f54f47848a1befd588b9ef66470
Source dataset
uspto-grants-1989_05
Patent number
US04835175

Reaction notes

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