Trimethyl phosphite → Dimethyl (Phthalimidomethyl)Phosphonate

HRID 1763477Notes

Reaction equation

Br[CH2:2][N:3]1[C:7](=[O:8])[C:6]2=[CH:9][CH:10]=[CH:11][CH:12]=[C:5]2[C:4]1=[O:13].[P:14]([O:19]C)([O:17][CH3:18])[O:15][CH3:16].BrCCN1C(=O)C2=CC=CC=C2C1=O.P(OCC)(OCC)OCC>>[C:7]1(=[O:8])[N:3]([CH2:2][P:14](=[O:19])([O:17][CH3:18])[O:15][CH3:16])[C:4](=[O:13])[C:5]2=[CH:12][CH:11]=[CH:10][CH:9]=[C:6]12

Participants

Reactant 4

HCID 8472Trimethyl phosphite

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-

HCID 31215Triethyl phosphite

HCID 792441H-Isoindole-1,3(2H)-dione, 2-(bromomethyl)-

Product 1

HCID 2773790Dimethyl (Phthalimidomethyl)Phosphonate

Procedure

Reaction of N-bromomethylphthalimide with trimethyl phosphite as described in Example 18 for N-(2-bromoethyl)phthalimide and triethyl phosphite gives dimethyl phthalimidomethylphosphonate.

Sources & evidence

ORD record: ord-5c70dcfee14849339d739b3b13e04deb
Source dataset: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04112086

Reaction notes

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