Hydrazine hydrate (1:1) → HCID 20310367, compound

HRID 1763595Notes

Reaction equation

HRID 1763595 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[C:5]([CH2:7][CH:8]([CH3:12])[C:9](O)=[O:10])=O.O.[NH2:17][NH2:18]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[CH2:7][CH:8]([CH3:12])[C:9](=[O:10])[NH:17][N:18]=2)[CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 5873544-(3-Chlorophenyl)-2-methyl-4-oxobutanoic acid

Product 1

HCID 20310367HCID 20310367, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 7.11 g. of 3-(m-chlorobenzoyl)-2-methylpropionic acid, 50 ml. of ethanol and 3.0 ml. of hydrazine hydrate is refluxed for 2 hrs. Cooling and filtering gives crystals, (m.p. 150°-151° C.) which are recrystallized from ethanol to give 5.72 g. of crystals, m.p. 152°-153°.

Workup

  1. additionA mixture of 7.11 g
  2. temperatureCooling
  3. filtrationfiltering
  4. customgives crystals, (m.p. 150°-151° C.) which
  5. customare recrystallized from ethanol
  6. customto give 5.72 g

Sources & evidence

ORD record
ord-42a48005974145e5a29d6b0ca72cd92f
Source dataset
uspto-grants-1978_09
Patent number
US04112095

Reaction notes

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