Hydrochloric Acid → HCID 178494286, compound

HRID 1763896Notes

Reaction equation

HRID 1763896 reaction equation
Cl.[Na].[OH:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([Cl:11])=[C:6](Cl)[N:5]=1.[CH3:13][OH:14]>>[OH:3][C:4]1[N:9]=[C:8]([CH3:10])[C:7]([Cl:11])=[C:6]([O:14][CH3:13])[N:5]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 5360545SodiumHCID 178433504HCID 178433504, compound

Product 1

HCID 178494286HCID 178494286, compoundYield 59%

Procedure

Hydrogen chloride gas was passed into a suspension of 80.4 g (0.4 mole) of the sodium salt of 2-hydroxy-4-methyl-5,6-dichloropyrimidine in 600 ml of methanol until the mixture reacted strongly acid. The mixture was then stirred for a further hour and thereafter the solvent was distilled off in vacuo. The residue was triturated with 50 ml of water and filtered off. 41.3 g (59% of theory) of 2-hydroxy-4-methyl-5-chloro-6-methoxy-pyrimidine were obtained in the form of a beige powder of melting point 235° C.

Workup

  1. customreacted strongly acid
  2. distillationthe solvent was distilled off in vacuo
  3. customThe residue was triturated with 50 ml of water
  4. filtrationfiltered off

Sources & evidence

ORD record
ord-8ef35975c1694a84856e28b5354fb197
Source dataset
uspto-grants-1978_09
Patent number
US04113860

Reaction notes

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