Hydrogen Bromide → HCID 20308591, compound

HRID 1763906Notes

Reaction equation

HRID 1763906 reaction equation
[CH3:1][N:2]([CH3:20])[S:3](=[O:19])(=[O:18])[O:4][C:5]1[C:10]([I:11])=[CH:9][C:8]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:7][C:6]=1[CH2:16][NH2:17].[BrH:21]>C(O)C>[BrH:21].[CH3:20][N:2]([CH3:1])[S:3](=[O:18])(=[O:19])[O:4][C:5]1[C:10]([I:11])=[CH:9][C:8]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:7][C:6]=1[CH2:16][NH2:17]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 12761816HCID 12761816, compound

Product 1

HCID 20308591HCID 20308591, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenyl N,N-dimethylsulfamate (65 mg., 0.16 millimole) in ethanol (2 ml.) is added slowly with stirring 48% hydrobromic acid (0.5 ml.) at 20° C. After standing at 20° C. for 15 minutes, the deposited solid is collected and dried to give 2-aminomethyl-4-(1,1-dimethylethyl)-6-iodophenyl N,N-dimethylsulfamate hydrobromide as a colorless solid (70 mg., 89%), m.p. 243°-244° C. with dec.

Workup

  1. customthe deposited solid is collected
  2. customdried

Sources & evidence

ORD record
ord-1f1120f96cd64f1f96122cf98be36035
Source dataset
uspto-grants-1978_09
Patent number
US04113877

Reaction notes

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