4-Ethylpyridine → 4-Ethylpyridin-2-amine

HRID 1764092Notes

Reaction equation

HRID 1764092 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2].[NH2-:9].[Na+]>>[NH2:9][C:5]1[CH:4]=[C:3]([CH2:1][CH3:2])[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 108224-EthylpyridineHCID 24533Sodium amide

Product 1

HCID 1184254-Ethylpyridin-2-amine

Procedure

This amine is prepared by the method of Case and Kasper from 4-ethylpyridine (Aldrich Chemical) and sodium amide (Fisher Scientific Co.) in 55% molar yield, mp 66°-70° (lit.1 70°-1°).

Sources & evidence

ORD record
ord-74c4f1531618433fb2d7d3a998896f8b
Source dataset
uspto-grants-1978_09
Patent number
US04115397

Reaction notes

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