反应详情

温度

50 °C

To 2.1 g of sodium in 150 ml of absolute ethanol are added with stirring 15 g of p-(1-cyclooctenyl)-phenol. After stirring has continued for a further 30 minutes, 30 g of 2-bromo-octanoic acid ethyl ester are slowly added dropwise to this solution and the mixture is maintained at 50° C for 24 hours. After the solvent has been removed in vacuo the residue is partitioned at 0° C between ether and 2N sodium hydroxide solutuion. The organic phase is washed until neutral, dried over sodium sulphate and evaporated in vacuo, to thus yield the oily α-[p-cyclooctenyl)-phenoxy]-octanoic acid ethyl ester of the formula ##STR9##

1. customAfter the solvent has been removed in vacuo the residue
2. customis partitioned at 0° C between ether and 2N sodium hydroxide solutuion
3. washThe organic phase is washed until neutral,
4. dry with materialdried over sodium sulphate
5. customevaporated in vacuo