Hydrochloric Acid → HCID 54413379, compound

HRID 1764207Notes

Reaction equation

HRID 1764207 reaction equation
[CH2:1]([C:4]1[N:9]2[CH:10]=[N:11][CH:12]=[C:8]2[C:7](=[O:13])[NH:6][N:5]=1)[CH2:2][CH3:3].C[O-].[Na+].[CH2:17](Br)[CH:18]=[CH2:19].Cl>CN(C)C=O.C(Cl)(Cl)Cl>[CH2:19]([N:5]1[CH:4]([CH2:1][CH2:2][CH3:3])[N:9]2[CH:10]=[N:11][CH:12]=[C:8]2[C:7](=[O:13])[NH:6]1)[CH:18]=[CH2:17]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 7841Allyl bromideHCID 10942334Sodium MethoxideHCID 12493319HCID 12493319, compound

Product 1

HCID 54413379HCID 54413379, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
20 °C

Procedure

To a solution of 4-n-propyl-imidazo[1,5-d]-as-triazin-1(2H)-one (0.01 mol) in dimethylformamide (50 ml) is added sodium methoxide (0.01 mol) followed by the addition of allyl bromide (0.012 mol). The reaction mixture is stirred at 20° C. for 16 hours, then heated at 40° C. for 45 minutes, cooled and poured on a mixture of ice and dilute hydrochloric acid. The product is isolated by extraction with chloroform and evaporation. It is purified by recrystallization from cyclohexane or a cyclohexane-benzene mixture; or by silica gel dry column chromatography in chloroform.

Workup

  1. temperatureheated at 40° C. for 45 minutes
  2. temperaturecooled
  3. customIt is purified by recrystallization from cyclohexane
  4. dry with materialor by silica gel dry column chromatography in chloroform

Sources & evidence

ORD record
ord-030850ff38694d379b92fc5f6b0de5bc
Source dataset
uspto-grants-1978_09
Patent number
US04115572

Reaction notes

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