反应详情

2,4-Diamino-5-hydroxymethylpyrimidine (1.4 g.), prepared as in Example 1, and 2,6-diethylphenol (1.6 g.) in toluene-4-sulphonic acid (10 g.) containing conc. hydrochloric acid (3 ml.) were heated on the steam-bath for 6 hours. The solution was cooled, diluted with ether and the ether decanted. The residue was treated with a soln. of sodium hydrogen carbonate and the solid filtered off. Recrystallisation from aqueous ethanol gave colourless needles of 2,4-diamino-5-(3,5-diethyl-4-hydroxybenzyl)pyrimidine, m.p. 200°-202° C.

1. temperaturewere heated on the steam-bath for 6 hours
2. temperatureThe solution was cooled
3. customthe ether decanted
4. additionThe residue was treated with a soln
5. filtrationof sodium hydrogen carbonate and the solid filtered off
6. customRecrystallisation from aqueous ethanol