Methanol → HCID 22768409, compound

HRID 1764505Notes

Reaction equation

HRID 1764505 reaction equation
[NH2:1][C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]2[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:4]=2[N:3]=1.CO.O.[NH2:24]N>C(O)(=O)C>[NH:1]([C:2]1[CH2:8][N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:5]2[CH:15]=[C:16]([O:19][CH3:20])[CH:17]=[CH:18][C:4]=2[N:3]=1)[NH2:24]

Participants

5

Reactant 3

HCID 887MethanolHCID 24654Hydrazine hydrate (1:1)HCID 12569812HCID 12569812, compound

Product 1

HCID 22768409HCID 22768409, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a mixture of 26.5 parts of 2-amino-7-methoxy-5-phenyl-3H-1,4-benzodiazepine, 500 parts by volume of methanol and 1.2 parts of glacial acetic acid is added 25 parts of 100% hydrazine hydrate. The mixture is stirred for 1 hour at room temperature and treated in a similar manner to Example 1, whereby 2-hydrazino-7-methoxy-5-phenyl-3H-1,4-benzodiazepine is yielded as crystals melting at 110° C to 120° C.

Workup

  1. additiontreated in a similar manner to Example 1

Sources & evidence

ORD record
ord-c8433aff2a224e5887ee6021a98fb895
Source dataset
uspto-grants-1978_09
Patent number
US04116956

Reaction notes

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