Acetic Acid → HCID 12875270, compound

HRID 1764571Notes

Reaction equation

HRID 1764571 reaction equation
C=O.[ClH:3].[CH3:4][C:5]1[S:6][C:7]([Cl:11])=[CH:8][C:9]=1[Cl:10].[C:12](O)(=O)C>>[Cl:3][CH2:12][C:8]1[C:9]([Cl:10])=[C:5]([CH3:4])[S:6][C:7]=1[Cl:11]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 128752653,5-Dichloro-2-methylthiophene

Product 1

HCID 12875270HCID 12875270, compound

Conditions

Temperature
70 °C

Procedure

8.6 G. (0.107 mol) off formalin and 90 ml. of concentrated hydrochloric acid were added to a solution of 10.87 g. (0.065 mol) of 2-methyl-3,5-dichlorothiophene in 45 ml. of acetic acid. The resulting mixture was heated to 70° C. for 18 hrs., cooled, poured into ice water and extracted with ether. The organic solution was washed with water, sodium bicarbonate and water, dried and evaporated to yield 3-chloromethyl-2,4-dichloro-5-methylthiophene as a crude oil.

Workup

  1. temperature, cooled
  2. extractionextracted with ether
  3. washThe organic solution was washed with water, sodium bicarbonate and water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-47d63f94b621427baf8d509b3ff27918
Source dataset
uspto-grants-1978_09
Patent number
US04116975

Reaction notes

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