反应详情

To a stirred solution of 2,4-difluoronitrobenzene (50 mmol), Et3N (100 mmol) and DMF (80 mL) was added dropwise a solution of n-butylamine (51 mmol) in DMF (20 mL) at rt, and the mixture was stirred at rt for 5 h. The reaction was quenched by cold H2O (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×60 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo to afford the desired 2-n-butylamino-4-fluoronitrobenzene which was used for further transformation.

1. customThe reaction was quenched by cold H2O (100 mL)
2. extractionthe resulting mixture was extracted with EtOAc (4×100 mL)
3. washThe combined EtOAc extracts were washed with brine (3×60 mL)
4. dry with materialdried (anhydrous Na2SO4)
5. customThe solvent was removed in vacuo