反应详情

Into the tetrahydrofuran (THF) (100 ml) solution containing 2,3,4-trifluorophenylacetylene (20 g), the THF solution (93 ml) of 1.5 M bromide methyl magnesium was added dropwise at 0° C., and stirred for 1 hour. Into this, the THF (50 ml) solution of trans-4-ethylcyclohexane carboaldehyde (18 g) was added dropwise, and stirred for 1 hour. The reaction solution was poured into 5% hydrochloric acid, extracted with ethyl acetate, and concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1) to obtain 1-(trans-4-ethylcyclohexyl)-3-(2,3,4-trifluorophenyl)-2-propyne-1-ol (38 g).

1. stirringstirred for 1 hour
2. extractionextracted with ethyl acetate
3. concentrationconcentrated
4. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1)