2,5-Dimethoxyaniline → HCID 22732369, compound

HRID 1765210Notes

Reaction equation

HRID 1765210 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[N:3]=1.[CH3:20][O:21][C:22]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:23]=1[NH2:24]>>[CH3:20][O:21][C:22]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:23]=1[NH:24][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)[N:3]=1

Participants

3

Reactant 2

HCID 76132,5-DimethoxyanilineHCID 27670664-Chloro-2,6-di(2-pyridinyl)pyrimidine

Product 1

HCID 22732369HCID 22732369, compound

Procedure

The title compound was prepared from a mixture 4-chloro-2,6-di(2-pyridinyl)pyrimidine (25 mg, 0.093 mmol) and 2,5-dimethoxyaniline (21 mg, 0.140 mmol) similar to Example 111 and isolated as a yellow oil (2 mg, 6%). 1H NMR (CDCl3): 8.86–8.84 (m, 1H), 8.70–8.64 (m, 3H), 8.11 (s, 1H), 7.92 (s, 1H), 7.91–7.85 (m, 2H), 7.65 (s, 1H), 7.43–7.36 (m, 2H), 6.87 (d, J=9.0 Hz, 1H), 6.61 (dd, J=3.0, 9.0 Hz, 1H), 3.89 (s, 3H), 3.86 (s, 3H).

Sources & evidence

ORD record
ord-88ed8bae459f4f3480702b157308807c
Source dataset
uspto-grants-2007_06
Patent number
US07226927B2

Reaction notes

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