Hexane → HCID 12133344, compound

HRID 1765337Notes

Reaction equation

HRID 1765337 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]([O:19][CH3:20])=[O:18])[CH:7]=[C:8]([CH:12]([CH3:14])[CH3:13])[C:9]=1[O:10]C)([CH3:3])[CH3:2].C(C1C=C(C=C(C(C)C)C=1OC)C=O)(C)C.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CCCCCC>C(OCC)C.CCCCCC>[CH3:20][O:19][C:17](/[CH:16]=[CH:15]/[C:6]1[CH:7]=[C:8]([CH:12]([CH3:14])[CH3:13])[C:9]([OH:10])=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:5]=1)=[O:18]

Participants

6

Reactant 4

HCID 8058HexaneHCID 11776TriphenylphosphineHCID 105850253,5-Diisopropyl-4-methoxybenzaldehydeHCID 69501695HCID 69501695, compound

Product 1

HCID 12133344HCID 12133344, compound

Reagents, catalysts & solvents 1

HCID 21584099Diethylether hexaneSolvent

Conditions

Temperature
50 °C

Procedure

Methyl 3-(3,5-diisopropyl-4-methoxyphenyl)acrylate. 3,5-diisopropyl-4-methoxybenzaldehyde (881 mg) free powder. Ph3P═CHCOOCH3 (1.7 g) was added, followed by 10 mL of hexane. The reaction mixture was heated at 50° C. for 24 hours, and the resulting mixture was loaded on a silica-gel column. Chromatography, with diethyl ether:hexane (10:90) as the eluent, provided the ester (944 mg).

Sources & evidence

ORD record
ord-aaa8edbc24624f5380abcecad7596102
Source dataset
uspto-grants-2007_06
Patent number
US07226946B2

Reaction notes

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