反应详情

温度

80 °C

7-Nitro-2-Isopropyl-4-bromo-2H-phthalazin-1-one (4.6 g, 0.015 mol) was dissolved in a 5:1 mixture of ethanol and water (150 ml). To this solution was added iron powder (2.14 g, 0.039 mol) and concentrated hydrochloric acid (1 ml), the mixture was heated to 80° C. for three hours. After this time, the reaction mixture was cooled to room temperature and filtered through a pad of celite, the celite was washed with ethanol (100 ml), and the solution was concentrated under vacuum to give the title compound (4.2 g, 98% yield) as a white solid.

1. temperatureAfter this time, the reaction mixture was cooled to room temperature
2. filtrationfiltered through a pad of celite
3. washthe celite was washed with ethanol (100 ml)
4. concentrationthe solution was concentrated under vacuum