Potassium Carbonate → 4-tert-Butyl-2-ethynyl-1-methyl-benzene

HRID 1765818Notes

Reaction equation

HRID 1765818 reaction equation
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH3:17])=[C:9]([C:11]#[C:12][Si](C)(C)C)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH3:17])=[C:9]([C:11]#[CH:12])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69070941(5-Tert-butyl-2-methyl-phenylethynyl)trimethyl-silane2×

Product 1

HCID 211071904-tert-Butyl-2-ethynyl-1-methyl-benzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following general procedure F and using (5-tert-butyl-2-methyl-phenylethynyl)-trimethyl-silane (Intermediate 109, 0.16 g, 0.66 mmol), methanol (5 mL) and potassium carbonate (0.05 g, 0.36 mmol), the title compound was obtained (0.08 g, 67%).

Sources & evidence

ORD record
ord-99fa2b0f3d3a400eaeab435dc07c3beb
Source dataset
uspto-grants-2007_06
Patent number
US07226951B2

Reaction notes

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