1,1'-Azobis(cyclohexanecarbonitrile) → Propofol

HRID 1765957Notes

Reaction equation

HRID 1765957 reaction equation
C(=O)(OC1C=CC(C=C)=CC=1)[O:2][C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[CH:7][CH:6]=[CH:5][C:4]=1[CH:12]([CH3:14])[CH3:13].C(C=C(C)C(O)=O)CC=C(C)C(O)=O.N(C1(C#N)CCCCC1)=NC1(C#N)CCCCC1>C1(C)C=CC=CC=1>[CH3:11][CH:9]([C:8]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:12]([CH3:14])[CH3:13])[C:3]=1[OH:2])[CH3:10]

Participants

5

Reactant 3

HCID 749781,1'-Azobis(cyclohexanecarbonitrile)HCID 58884383HCID 58884383, compoundHCID 85593397HCID 85593397, compound

Product 1

HCID 4943Propofol

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The polymerisation carried in a manner similar to that Whitcombe et al. The Molar ratio used was of (2,6-diisopropyl)phenyl (4-vinylphenyl) carbonate to crosslinker (ethylenedimethacrylic acid) to 1,1′-azobis(cyclohexanecarbonitrile) (ABCHC) was 1:19:0.125 for bulk and 1:1:0.125 for membranes, 2 ml/g monomers as porogen (toluene). The polymerisation took 48 hors to complete at 60–80° C. for bulk polymer and 24 hours for the membranes.

Workup

  1. customto complete at 60–80° C. for bulk polymer and 24 hours for the membranes

Sources & evidence

ORD record
ord-a226ae32474d4ca1abbe2d3d66ccaf9b
Source dataset
uspto-grants-2007_06
Patent number
US07229836B2

Reaction notes

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