Ethanol → HCID 21109100, compound

HRID 1766099Notes

Reaction equation

HRID 1766099 reaction equation
CCN(C(C)C)C(C)C.C([N:12]1[C:17]([S:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:16]([C:25]#[N:26])[C:15]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([N+:33]([O-:35])=[O:34])[CH:28]=2)=[N:14][CH:13]1[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)C.CCO>C1(C)C=CC=CC=1>[NH2:26][C:25]1[C:16]2[C:15]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([N+:33]([O-:35])=[O:34])[CH:28]=3)=[N:14][C:13]([C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)=[N:12][C:17]=2[S:18][C:19]=1[C:20]([O:22][CH2:23][CH3:24])=[O:21]

Participants

5

Reactant 3

HCID 702EthanolHCID 81531DiisopropylethylamineHCID 69037797HCID 69037797, compound

Product 1

HCID 21109100HCID 21109100, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
0 °C

Procedure

DIPEA (20.0 ml) was added to a stirred solution of ethyl 5-cyano-4(3-nitrophenyl)-2-phenyl-6-(ethoxycarbonylmethylthio)-pyrimidine (example 31(c), 19.7 g) in a mixture of abs. EtOH (100 ml) and toluene p.a. (100 ml). After 48 h at 100° C., the mixture was cooled to 0° C. The resulting precipitate was filtered off, washed with cold EtOH and dried in vacuo at 40° C.

Workup

  1. filtrationThe resulting precipitate was filtered off
  2. washwashed with cold EtOH
  3. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-32c51771d34c4b628441a8cc4d5c7cba
Source dataset
uspto-grants-2007_06
Patent number
US07229990B2

Reaction notes

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