Dimethyl malonate → HCID 13221084, compound

HRID 1766351Notes

Reaction equation

HRID 1766351 reaction equation
[C:1]([O:8][CH3:9])(=[O:7])[CH2:2][C:3]([O:5][CH3:6])=[O:4].[C:10]([C:12]1[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=1)#[N:11].N1CCCCC1>CO>[C:10]([C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[C:2]([C:1]([O:8][CH3:9])=[O:7])[C:3]([O:5][CH3:6])=[O:4])=[CH:14][CH:13]=1)#[N:11]

Participants

5

Reactant 3

HCID 7943Dimethyl malonateHCID 8082PiperidineHCID 660424-Cyanobenzaldehyde

Product 1

HCID 13221084HCID 13221084, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dimethyl malonate (5.04 g, 38.13 mmol), 4-cyanobenzaldehyde (5.00 g, 38.13 mmol) and piperidine (0.097 g, 1.1 mmol) are dissolved in methanol (150 ml). The reaction mixture is stirred for two days (48 hours) at room temperature. The solvent is removed in vacuo to afford a viscous oil which is recrystallised from methanol.

Workup

  1. customThe solvent is removed in vacuo
  2. customto afford a viscous oil which
  3. customis recrystallised from methanol

Sources & evidence

ORD record
ord-889d7d0f9f01452f9dbc336cc2bd8657
Source dataset
uspto-grants-2007_06
Patent number
US07230017B2

Reaction notes

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