2-Methoxyethylamine → HCID 21110162, compound

HRID 1766353Notes

Reaction equation

HRID 1766353 reaction equation
Cl[C:2](=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH3:10][O:11][CH2:12][CH2:13][NH2:14]>O1CCCC1>[CH3:10][O:11][CH2:12][CH2:13][NH:14][C:2](=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 118931Ethyl 3-chloro-3-oxopropionate

Product 1

HCID 21110162HCID 21110162, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2.0 g (13.3 mmol) Ethyl 3-chloro-3-oxopropanoate are dissolved in 50 ml tetrahydrofuran and 2.99 g (39.85 mmol) 2-methoxyethylamine are added at 0° C. The reaction mixture is stirred at room temperature for 18 hours. The solvent is removed in vacuo and the product is isolated by column chromatography (silica, eluent dichloromethane/methanol 50:1).

Workup

  1. customThe solvent is removed in vacuo
  2. customthe product is isolated by column chromatography (silica, eluent dichloromethane/methanol 50:1)

Sources & evidence

ORD record
ord-665c4e5da6ae4417b4bf91382b74be2e
Source dataset
uspto-grants-2007_06
Patent number
US07230017B2

Reaction notes

Loading…