HCID 23031211, compound → HCID 23031157, compound

HRID 1766671Notes

Reaction equation

HRID 1766671 reaction equation
[CH2:1]([O:8][C:9]1[CH:28]=[CH:27][C:12]([O:13][C:14]2[C:22]([CH3:23])=[CH:21][C:20]([N+:24]([O-])=O)=[C:19]3[C:15]=2[CH2:16][CH2:17][CH2:18]3)=[CH:11][C:10]=1[I:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pt]>[CH2:1]([O:8][C:9]1[CH:28]=[CH:27][C:12]([O:13][C:14]2[C:22]([CH3:23])=[CH:21][C:20]([NH2:24])=[C:19]3[C:15]=2[CH2:16][CH2:17][CH2:18]3)=[CH:11][C:10]=1[I:29])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 23031211HCID 23031211, compound

Product 1

HCID 23031157HCID 23031157, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(4-benzyloxy-3-iodophenoxy)-5-methyl-7-nitroindane (4.18 g) in ethyl acetate (15 mL) was added 5% Pt/C (860 mg). The mixture was stirred under a hydrogen atmosphere at room temperature for 2 hours. The insoluble material was removed by filtration. The filtrate was evaporated under reduced pressure to dryness to give the title compound (3.89 g).

Workup

  1. customThe insoluble material was removed by filtration
  2. customThe filtrate was evaporated under reduced pressure to dryness

Sources & evidence

ORD record
ord-35ea508b85fe41f187ec019d1bcf844f
Source dataset
uspto-grants-2007_06
Patent number
US07230031B2

Reaction notes

Loading…