HCID 23031175, compound → HCID 23031151, compound

HRID 1766682Notes

Reaction equation

HRID 1766682 reaction equation
C([N:8](CC1C=CC=CC=1)[C:9]1[CH:17]=[C:16]([CH3:18])[C:15]([O:19][C:20]2[CH:25]=[CH:24][C:23]([O:26]CC3C=CC=CC=3)=[C:22]([C:34]([CH3:36])=[CH2:35])[C:21]=2[O:37][CH3:38])=[C:14]2[C:10]=1[CH2:11][CH2:12][CH2:13]2)C1C=CC=CC=1.[H][H]>O1CCCC1.[Pd]>[NH2:8][C:9]1[CH:17]=[C:16]([CH3:18])[C:15]([O:19][C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[C:22]([CH:34]([CH3:36])[CH3:35])[C:21]=2[O:37][CH3:38])=[C:14]2[C:10]=1[CH2:11][CH2:12][CH2:13]2

Participants

5

Reactant 2

HCID 23031175HCID 23031175, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23031151HCID 23031151, compoundYield 98.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of dibenzyl[7-(4-benzyloxy-3-isopropenyl-2-methoxyphenoxy)-6-methylindan-4-yl]amine (7.97 g) in tetrahydrofuran (80 mL) was added 10% Pd/C (4.00 g). The mixture was stirred at room temperature under an atmospheric pressure of hydrogen overnight. The insoluble material was removed by filtration. The filtrate was evaporated under reduced pressure to dryness to give the title compound (4.33 g).

Workup

  1. customThe insoluble material was removed by filtration
  2. customThe filtrate was evaporated under reduced pressure to dryness

Sources & evidence

ORD record
ord-cc69c34861514b92be5b3f20181793be
Source dataset
uspto-grants-2007_06
Patent number
US07230031B2

Reaction notes

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