反应详情

温度

90 °C

To a stirred solution of 4-fluoronitrobenzene (20 mmol), 4-fluoro-3-trifluoromethylphenol (22 mmol) in DMF (50 mL) at rt, solid potassium carbonate (60 mmol) was added, and the reaction mixture was heated to 90° C. for 5 h (monitored by TLC), according to General Procedure L1. After cooling to rt, the reaction mixture was poured into cold H2O (60 mL). The resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with H2O (2×40 mL) and brine (50 mL), and dried over anhydrous sodium sulfate. The solvent was removed in vacuuo to afford the desired 1-fluoro-4-(4-nitrophenoxy)-2-(trifluoromethyl)benzene. The crude product was used directly for further transformation without further purification.

1. temperatureAfter cooling to rt
2. extractionThe resulting mixture was extracted with EtOAc (3×100 mL)
3. washThe combined EtOAc extracts were washed with H2O (2×40 mL) and brine (50 mL)
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was removed in vacuuo