Trifluoroacetic acid → HCID 17862676, compound

HRID 1766877Notes

Reaction equation

[CH2:1]([O:4][P:5]([O:11][CH2:12][C:13]1[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:14]=1[C:15]([O:17]CC1C=CC(OC)=CC=1)=[O:16])([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])[CH:2]=[CH2:3].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>>[CH2:1]([O:4][P:5]([O:11][CH2:12][C:13]1[C:30]([F:31])=[CH:29][CH:28]=[CH:27][C:14]=1[C:15]([OH:17])=[O:16])([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])[CH:2]=[CH2:3]

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 17862558HCID 17862558, compound

Product 1

HCID 17862676HCID 17862676, compound

Procedure

According to a similar procedure to that described in Example 4-(6), 4-methoxybenzyl 2-[[bis(allyloxy)phosphoryl]oxymethyl]-3-fluorobenzoate (1.40 g, 3.12 mmol) obtained in Example 6-(1) was reacted with anisole (1.4 g, 12.9 mmol) and trifluoroacetic acid (5 ml), and the reaction mixture was worked up to afford 2-[[bis(allyloxy)phosphoryl]oxymethyl]-3-fluorobenzoic acid as a crude product. According to a similar procedure to that described in Example 4-(6), the crude product obtained above, oxalyl chloride (1.98 g, 15.6 mmol), and N,N-dimethylformamide (15 μl) were reacted, and the reaction mixture was worked up to afford 2-[[bis(allyloxy)phosphoryl]oxymethyl]-3-fluorobenzoyl chloride as a crude product.

Sources & evidence

ORD record: ord-0ddd7a59430048438574cf7f7fd05726
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07230023B2

Reaction notes

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