Trifluoroacetic acid → HCID 21110464, compound

HRID 1766891Notes

Reaction equation

HRID 1766891 reaction equation
[CH2:1]([O:4][P:5]([O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17]CC1C=CC(OC)=CC=1)=[O:16])([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])[CH:2]=[CH2:3].C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>C1(C)C=CC=CC=1>[CH2:8]([O:7][P:5]([O:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])([O:4][CH2:1][CH:2]=[CH2:3])=[O:6])[CH:9]=[CH2:10]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 17862550HCID 17862550, compound

Product 1

HCID 21110464HCID 21110464, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a mixture of 4-methoxybenzyl 4-[[bis(allyloxy)phosphoryl]oxy]butyrate (700 mg, 1.82 mmol) obtained from Example 13-(1) and anisole (0.7 ml) was added trifluoroacetic acid (3 ml) at room temperature. The mixture was stirred at room temperature for 15 minutes, then diluted with toluene, and the solvent was distilled off under reduced pressure. The residue was redissolved in toluene, and the solvent was distilled off under reduced pressure to give crude 4-[[bis(allyloxy)phosphoryl]oxy]butanoic acid as a pale yellow oil.

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. dissolutionThe residue was redissolved in toluene
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-99260663d80e4598be370e8fdcb829bb
Source dataset
uspto-grants-2007_06
Patent number
US07230023B2

Reaction notes

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