Anisole → HCID 21110439, compound

HRID 1766900Notes

Reaction equation

HRID 1766900 reaction equation
[CH2:1]([O:4][C:5]([O:7][CH2:8][C:9]1[CH:26]=[CH:25][CH:24]=[CH:23][C:10]=1[C:11]([O:13]CC1C=CC(OC)=CC=1)=[O:12])=[O:6])[CH:2]=[CH2:3].C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O.C1(C)C=CC=CC=1>[CH2:1]([O:4][C:5]([O:7][CH2:8][C:9]1[CH:26]=[CH:25][CH:24]=[CH:23][C:10]=1[C:11]([OH:13])=[O:12])=[O:6])[CH:2]=[CH2:3]

Participants

5

Reactant 2

HCID 7519AnisoleHCID 21110472HCID 21110472, compound

Product 1

HCID 21110439HCID 21110439, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of 4-methoxybenzyl 2-[(allyloxycarbonyl)oxymethyl]benzoate (6.80 g, 19.1 mmol) obtained from Example 17-(1) and anisole (5 g) was dissolved in trifluoroacetic acid (10 ml) at room temperature. The mixture was stirred for 15 minutes, then diluted with toluene, and the solvent was distilled off under reduced pressure. The residue was washed with hexane to afford the crude title compound (3.87 g, 86%) as a colorless solid.

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. washThe residue was washed with hexane

Sources & evidence

ORD record
ord-e195faf196f54b55a8fa43b27547f296
Source dataset
uspto-grants-2007_06
Patent number
US07230023B2

Reaction notes

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