HCID 58677164, compound → HCID 21113154, compound

HRID 1767045Notes

Reaction equation

HRID 1767045 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[C:13]1[N:14]=[C:15]([CH2:18][CH2:19][NH:20]C(=O)OC(C)(C)C)[S:16][CH:17]=1>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[C:13]1[N:14]=[C:15]([CH2:18][CH2:19][NH2:20])[S:16][CH:17]=1

Participants

3

Reactant 1

HCID 58677164HCID 58677164, compound

Product 1

HCID 21113154HCID 21113154, compoundYield 315.8%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The carbamate (c) (0.93 g, 2.4 mmol) was dissolved in trifluoroacetic acid (40 mL). After 1 hour the mixture was evaporated and the residue partitioned between ethyl acetate and aqueous sodium bicarbonate solution. The organic extract was washed with brine, dried and evaporated affording a solid (2.17 g, 90%).

Workup

  1. customAfter 1 hour the mixture was evaporated
  2. customthe residue partitioned between ethyl acetate and aqueous sodium bicarbonate solution
  3. extractionThe organic extract
  4. washwas washed with brine
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-5afe1bae52d84968ae274f610afd5180
Source dataset
uspto-grants-2007_06
Patent number
US07232832B2

Reaction notes

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