Potassium Carbonate → HCID 135830901, compound

HRID 1767051Notes

Reaction equation

HRID 1767051 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9]([O:11]CC)=O)=[CH:3][CH:2]=1.Cl.Cl.[NH2:17][C:18]1[NH:23][CH2:22][CH2:21][CH2:20][N:19]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[N:17]=[C:18]3[NH:23][CH2:22][CH2:21][CH2:20][N:19]3[C:9](=[O:11])[CH:8]=2)=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2735202Ethyl 3-(4-pyridyl)-3-oxopropionateHCID 17851068HCID 17851068, compound

Product 1

HCID 135830901HCID 135830901, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 8.98 g (46.5 mmol) of ethyl 3-(4-pyridyl)-3-oxopropionate and 8.0 g (46.5 mmol) of 2-amino-3,4,5,6-tetrahydropyrimidine dihydrochloride (prepared according to J. Org. Chem. 1955, 20, 829) and 19.3 g (139.5 mmol) of potassium carbonate in 60 ml of ethanol was heated at reflux temperature during 18 h.

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperature during 18 h.

Sources & evidence

ORD record
ord-de806a1e06e0465ab764d479b51e6f5a
Source dataset
uspto-grants-2007_06
Patent number
US07232827B2

Reaction notes

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