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HRID1767872

反应详情

EQUATION

反应方程式

HRID 1767872 的结构方程式

REACTANTS

反应物

3
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC(C)(C)OC(=O)CBr
HCID79177

Acetic acid, bromo-, 1,1-dimethylethyl ester

C6H11BrO2

结构：Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(C)Oc1ccc2cc[nH]c2c1
HCID23614515

6-(1-{4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethoxy)-1H-indole

C21H17F3N2OS

PRODUCTS

生成物

1
结构：Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1C(C)Oc1ccc2ccn(CC(=O)OC(C)(C)C)c2c1
HCID69279692

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In analogy to the procedure described in example 1 b], [rac]-6-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-1H-indole was reacted with bromo-acetic acid tert-butyl ester in the presence of sodium hydride in DMF to yield [rac]-(6-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester as colorless gum.