Potassium Iodide → HCID 69280203, compound

HRID 1767910Notes

Reaction equation

HRID 1767910 reaction equation
[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([OH:15])=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2].Cl[CH:18]([C:20]1[S:24][C:23]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)=[N:22][C:21]=1[CH3:35])[CH3:19].C(=O)([O-])[O-].[Cs+].[Cs+].[I-].[K+]>CN(C)C=O>[CH2:1]([O:3][C:4](=[O:16])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH:18]([C:20]3[S:24][C:23]([C:25]4[CH:26]=[CH:27][C:28]([C:31]([F:33])([F:34])[F:32])=[CH:29][CH:30]=4)=[N:22][C:21]=3[CH3:35])[CH3:19])=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)[CH3:2]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 10796Cesium carbonateHCID 236145145-(1-Chloroethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazoleHCID 57675474(5-Hydroxy-indol-1-yl)-acetic acid ethyl ester

Product 1

HCID 69280203HCID 69280203, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 1 a], (5-hydroxy-indol-1-yl)-acetic acid ethyl ester was reacted with [rac)-5-(1-chloro-ethyl)-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole in the presence of cesium carbonate and potassium iodide in N,N-dimethylformamide for 4 h at ambient temperature to give the title compound as yellow solid.

Sources & evidence

ORD record
ord-7b5ec86f9ea7496f8b6cdf283793b555
Source dataset
uspto-grants-2007_06
Patent number
US07235572B2

Reaction notes

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