反应详情

25.0 mg (0.100 mmol) 95% sodium hydride were given to a solution of 216 mg (0.100 mmol) 4-(4-[Imidazol-1-yl]-butyl)-phenol in 5.0 ml DMF and stirred for 15 min. 346 mg (0.100 mmol) 4-chloromethyl-2-[2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazole were added and stirring continued overnight. After addition of 10 ml water the resulting precipitate was isolated and washed with 2×10 ml water, 2×10 ml methanol and with diethyl ether. Yield 411 mg (78%). MS: M=526.2 (ESI+)

1. stirringstirring continued overnight
2. customwas isolated
3. washwashed with 2×10 ml water, 2×10 ml methanol and with diethyl ether