反应详情

13 mg (0.50 mmol) 95% sodium hydride were given to a solution of 108 mg (0.50 mmol) 4-(4-[1,2,3]triazol-1-yl-but-1-enyl)-phenol in 4.0 ml DMF and stirred for 15 min. 173 mg (0.50 mmol) 4-chloromethyl-2-[2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazole were added and stirring continued at r.t. overnight. After addition of 10 ml water the resulting precipitate was collected, washed with water (2×10 ml), methanol (2×10 ml), diethyl ether and dried in vacuum at 40° C. to yield 225 mg (86%) of product.

1. stirringstirring
2. waitcontinued at r.t. overnight
3. customwas collected
4. washwashed with water (2×10 ml), methanol (2×10 ml), diethyl ether
5. customdried in vacuum at 40° C.