Water → HCID 72968178, compound

HRID 1768078Notes

Reaction equation

HRID 1768078 reaction equation
[H-].[Na+].[N:3]1([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH:7]=[CH:6][N:5]=[N:4]1.Cl[CH2:20][C:21]1[N:22]=[C:23]([CH:26]=[CH:27][C:28]2[CH:33]=[CH:32][C:31]([S:34]([F:39])([F:38])([F:37])([F:36])[F:35])=[CH:30][CH:29]=2)[O:24][CH:25]=1.O>CN(C=O)C>[F:37][S:34]([F:35])([F:36])([F:38])([F:39])[C:31]1[CH:32]=[CH:33][C:28]([CH:27]=[CH:26][C:23]2[O:24][CH:25]=[C:21]([CH2:20][O:18][C:15]3[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][CH2:8][N:3]4[CH:7]=[CH:6][N:5]=[N:4]4)=[CH:17][CH:16]=3)[N:22]=2)=[CH:29][CH:30]=1

Participants

6

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 23614541HCID 23614541, compoundHCID 865985174-Chloromethyl-2-[2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazole

Product 1

HCID 72968178HCID 72968178, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

14 mg (0.55 mmol) 95% sodium hydride were given to a solution of 110 mg (0.50 mmol) 4-(3-[1,2,3]triazol-1-yl-propoxy)-phenol in 4.0 ml DMF and stirred for 15 min. 173 mg (0.50 mmol) 4-chloromethyl-2-[2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazole were added and stirring continued at r.t. overnight. After addition of 8 ml water the resulting precipitate was collected , washed with water (2×10 ml), methanol/water 1:1 (2×10 ml), ethyl acetate/n-heptane 1:2, a small amount of diethyl ether and dried to yield 233 mg (88%) of a slightly yellow powder.

Workup

  1. stirringstirring
  2. waitcontinued at r.t. overnight
  3. customwas collected
  4. washwashed with water (2×10 ml), methanol/water 1:1 (2×10 ml), ethyl acetate/n-heptane 1:2
  5. dry with materiala small amount of diethyl ether and dried
  6. customto yield 233 mg (88%) of a slightly yellow powder

Sources & evidence

ORD record
ord-f39bb1a1b55b4602bead4550f6012d2b
Source dataset
uspto-grants-2007_06
Patent number
US07235574B2

Reaction notes

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