Methylamine → (RS)-2-Oxo-1-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic Acid Methylamide
Reaction equation
[O:1]=[C:2]1[CH:6]([C:7](O)=[O:8])[CH2:5][CH2:4][N:3]1[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:12][CH:11]=1.[CH3:28][NH2:29]>>[CH3:28][NH:29][C:7]([CH:6]1[CH2:5][CH2:4][N:3]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=3)=[CH:12][CH:11]=2)[C:2]1=[O:1])=[O:8]Participants
3
Procedure
The title compound is prepared in analogy to Example 6d) from (RS)-2-oxo-1-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid and methylamine. Yield: 6% of a colorless solid. MS: m/e=393.2 (M+H)+.
Sources & evidence
- ORD record
- ord-92b3761a1c70436490085d34bdb5b909
- Source dataset
- uspto-grants-2007_06
- Patent number
- US07235581B2
Reaction notes
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