Ammonium Hydroxide → 1-Amino-3-(morpholin-4-yl)propan-2-ol

HRID 1768582Notes

Reaction equation

[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH:8]2[O:10][CH2:9]2)[CH2:3][CH2:2]1.[OH-].[NH4+:12]>>[NH2:12][CH2:9][CH:8]([OH:10])[CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 977514-(2,3-Epoxypropyl)morpholine

Product 1

HCID 28322311-Amino-3-(morpholin-4-yl)propan-2-ol

Procedure

500 mg of the 1-morpholino-2,3-epoxypropane prepared as described above were dissolved in 20 ml of a saturated methanolic solution of ammonium hydroxide, and the mixture was allowed to stand at room temperature for 3 days. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, to give 530 mg of 1-amino-3-morpholino-2-propanol.

Workup

concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure

Sources & evidence

ORD record: ord-5151632d7afd4b3d9358acd55cb4f46f
Source dataset: uspto-grants-1995_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05378690

Reaction notes

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