Ammonium Hydroxide → 4-(2,2-Dimethyl-1-oxopropyl)-benzamide

HRID 1768668Notes

Reaction equation

HRID 1768668 reaction equation
[CH3:1][C:2]([CH3:15])([CH3:14])[C:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1)=[O:4].[OH-].[NH4+:17]>C(OCC)C>[CH3:1][C:2]([CH3:15])([CH3:14])[C:3]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:17])=[O:10])=[CH:7][CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 11806342Benzoyl chloride, 4-(2,2-dimethyl-1-oxopropyl)-

Product 1

HCID 105362344-(2,2-Dimethyl-1-oxopropyl)-benzamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3.1 grams (14 mmoles) of 4-(2,2-dimethyl-1-oxopropyl) benzoyl chloride is dissolved in 15 milliliters of diethylether, and the resulting solution is added dropwise to concentrated ammonium hydroxide with vigorous stirring at 0°-10° C. The white crystalline precipitate which forms is filtered off and washed with water and with ether. The product is dried in vacuo to yield 4-(2,2-dimethyl-1-oxopropyl)-benzamide (m.p. 138°-140° C.) .

Workup

  1. filtrationThe white crystalline precipitate which forms is filtered off
  2. washwashed with water and with ether
  3. customThe product is dried in vacuo

Sources & evidence

ORD record
ord-c2026af84a9c48859b4457e392ef8c5d
Source dataset
uspto-grants-1995_01
Patent number
US05378728

Reaction notes

Loading…