Hydroxylamine → HCID 14860691, compound

HRID 1768679Notes

Reaction equation

HRID 1768679 reaction equation
Br[CH:2]([NH:8][C:9](=[O:11])[CH3:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH2:12][OH:13]>>[C:9]([NH:8][CH:2]([NH:12][OH:13])[C:3]([O:5][CH2:6][CH3:7])=[O:4])(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 787HydroxylamineHCID 13082363HCID 13082363, compound

Product 1

HCID 14860691HCID 14860691, compound

Procedure

Using ethyl 2-bromo-2-acetamidoacetate (2.10 g, 9.37 mmol) and anhydrous NH2OH (0.93 g, 28.00 mmol) gave an oily residue. The residue was purified by flash column chromatography on SiO2 gel (5% MeOH/CHCl3) to give the desired product. The product was recrystallized from EtOH to give a white flaky solid.

Workup

  1. customgave an oily residue
  2. customThe residue was purified by flash column chromatography on SiO2 gel (5% MeOH/CHCl3)

Sources & evidence

ORD record
ord-c35714798ac14a179f5cfc1d036be82c
Source dataset
uspto-grants-1995_01
Patent number
US05378729

Reaction notes

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