反应详情

To a solution of one gram of 2-iodo-5-hydroxypyridine (prepared as by Edgar, K. J. & Falling, S. N.; (1990) J. Org. Chem., 55: 5287) in dimethylformamide (14 ml) was added cesium carbonate (1.55 g) and bromooctane (1.56 ml). The reaction was allowed to stir for 100 hrs, at which time it was poured into water and extracted with 1:1 hexane:ethyl acetate. The combined organics were washed with brine and dried over sodium sulfate and potassium carbonate. The solvent was removed in vacuo to give a yellow oil. This oil was purified by flash chromatography using 10% ethyl acetate in hexanes as the eluent, giving a clear oil as a product.

1. extractionextracted with 1:1 hexane
2. washThe combined organics were washed with brine
3. dry with materialdried over sodium sulfate and potassium carbonate
4. customThe solvent was removed in vacuo
5. customto give a yellow oil
6. customThis oil was purified by flash chromatography
7. customgiving a clear oil as a product